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LGALS3 / Galectin 3 Antibody (clone 1G8)

Mouse Monoclonal Antibody

     
  • WB - LGALS3 / Galectin 3 Antibody (clone 1G8) ALS15829
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGALS3...
    detail
  • WB - LGALS3 / Galectin 3 Antibody (clone 1G8) ALS15829
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-LGALS3 monoclonal...
    detail
  • IF - LGALS3 / Galectin 3 Antibody (clone 1G8) ALS15829
    Immunofluorescent staining of HeLa cells using anti-LGALS3 mouse monoclonal antibody.
    detail
  • IHC - LGALS3 / Galectin 3 Antibody (clone 1G8) ALS15829
    Anti-LGALS3 / Galectin 3 antibody IHC staining of human small intestine.
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P17931
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1G8
Calculated MW 26kDa
Dilution IF (1:100), IHC-P (10 µg/ml), WB (1:200-1:4000)
Additional Information
Gene ID 3958
Other Names Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, LGALS3, MAC2
Target/Specificity Human MAC-2 / Galectin-3
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsLGALS3 / Galectin 3 Antibody (clone 1G8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LGALS3 (HGNC:6563)
Synonyms MAC2
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=Secreted by a non- classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).
Tissue Location A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

References

Robertson M.W.,et al.Biochemistry 29:8093-8100(1990).
Cherayil B.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7324-7328(1990).
Oda Y.,et al.Gene 99:279-283(1991).
Raz A.,et al.Cancer Res. 51:2173-2178(1991).
Lotz M.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3466-3470(1993).

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Discontinued
Cat# ALS15829
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