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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HAS2 Antibody (clone 4E7)   

HAS2 Antibody (clone 4E7)

Mouse Monoclonal Antibody

     
  • WB - HAS2 Antibody (clone 4E7) ALS15837
    Western blot using HAS2 mouse monoclonal antibody against NTERA-2 (1), HEK293 (2) cell lysate.
  • IF - HAS2 Antibody (clone 4E7) ALS15837
    Immunofluorescence of HeLa cells using HAS2 mouse monoclonal antibody (green).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession Q92819
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4E7
Calculated MW 64kDa
Dilution ELISA (1:10000), ICC (1:100-1:500), IF (1:500), IHC-P (10 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 3037
Other Names Hyaluronan synthase 2, 2.4.1.212, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2
Target/Specificity Human HAS2
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsHAS2 Antibody (clone 4E7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAS2
Function Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Expressed in fibroblasts.
Volume 50 µl
Research Areas
Citations (0)

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Background

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).

References

Watanabe K.,et al.J. Biol. Chem. 271:22945-22948(1996).
Morerio C.,et al.Cancer Genet. Cytogenet. 156:183-184(2005).

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$ 395.00
Cat# ALS15837
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