|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Other Names||Thymidylate synthase, TS, TSase, 22.214.171.124, TYMS, TS|
|Target/Specificity||Recognizes human Thymidylate Synthase and is useful in determining its presence in various assays. Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic ...|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TS / Thymidylate Synthase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Takeishi K.,et al.Nucleic Acids Res. 13:2035-2043(1985).
Kaneda S.,et al.J. Biol. Chem. 265:20277-20284(1990).
Hisatomi H.,et al.Cancer Lett. 193:127-131(2003).
Shichijo S.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 437:551-555(2005).
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