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MICU1 / CBARA1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - MICU1 / CBARA1 Antibody (Internal) ALS15846
    Anti-MICU1 / CBARA1 antibody IHC staining of human lung, respiratory epithelium.
  • WB - MICU1 / CBARA1 Antibody (Internal) ALS15846
    CBARA1 antibody (0.5 ug/ml) staining of K562 lysate (35 ug protein/ml in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BPX6
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Goat, Horse, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 54kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 10367
Other Names Calcium uptake protein 1, mitochondrial, Atopy-related autoantigen CALC, ara CALC, Calcium-binding atopy-related autoantigen 1, Hom s 4, MICU1, CALC, CBARA1
Target/Specificity Human CBARA1. This antibody is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMICU1 / CBARA1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MICU1
Synonyms CALC, CBARA1
Function Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Cellular Location Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space Note=Localizes at the outer surface of the mitochondrion inner membrane
Tissue Location Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Natter S.,et al.FASEB J. 12:1559-1569(1998).

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$ 395.00
Cat# ALS15846
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