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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SPTLC2 / LCB2 Antibody (C-Terminus)   

SPTLC2 / LCB2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SPTLC2 / LCB2 Antibody (C-Terminus) ALS15849
    Anti-SPTLC2 / LCB2 antibody IHC staining of human adrenal.
  • ICC - SPTLC2 / LCB2 Antibody (C-Terminus) ALS15849
    Immunocytochemistry of SPT2 in 3T3 cells with SPT2 antibody at 10 µg/mL.
  • IF - SPTLC2 / LCB2 Antibody (C-Terminus) ALS15849
    Immunofluorescence of SPT2 in 3T3 cells with SPT2 antibody at 20 µg/mL.
  • WB - SPTLC2 / LCB2 Antibody (C-Terminus) ALS15849
    Western blot analysis of SPT2 in 3T3 cell lysate with SPT2 antibody at (A) 0.25 and (B) 0.5 ug/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession O15270
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 63kDa
Dilution ICC (10 µg/ml), IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) ,
Additional Information
Gene ID 9517
Other Names Serine palmitoyltransferase 2, 2.3.1.50, Long chain base biosynthesis protein 2, LCB 2, Long chain base biosynthesis protein 2a, LCB2a, Serine-palmitoyl-CoA transferase 2, SPT 2, SPTLC2, KIAA0526, LCB2
Target/Specificity Human SPTLC2. At least three isoforms of SPT2 are known to exist; this antibody will not detect isoform b. SPT2 antibody is predicted to not cross-react with SPT1.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSPTLC2 / LCB2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPTLC2
Synonyms KIAA0526, LCB2
Function Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.

References

Weiss B.,et al.Eur. J. Biochem. 249:239-247(1997).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Heilig R.,et al.Nature 421:601-607(2003).
Nagiec M.M.,et al.Gene 177:237-241(1996).
Takeda J.,et al.Hum. Mol. Genet. 2:1793-1798(1993).

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$ 395.00
Cat# ALS15849
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