|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||Ras association domain-containing protein 10, RASSF10|
|Target/Specificity||Human RASSF10. RASSF10 antibody will not cross-react with other RAS association domain-containing family members.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||RASSF10 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm|
|Tissue Location||Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.|
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Provided below are standard protocols that you may find useful for product applications.
Taylor T.D.,et al.Nature 440:497-500(2006).
Sherwood V.,et al.Mol. Biol. Cell 19:1772-1782(2008).
Hill V.K.,et al.Oncogene 30:978-989(2011).
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