CCDC141 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q6ZP82 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 166kDa |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml) |
Gene ID | 285025 |
---|---|
Other Names | Coiled-coil domain-containing protein 141, Coiled-coil protein associated with myosin II and DISC1, CCDC141, CAMDI {ECO:0000303|PubMed:20956536} |
Target/Specificity | Human CCDC141. At least four isoforms of CCDC141 are known to exist. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | CCDC141 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCDC141 |
---|---|
Synonyms | CAMDI {ECO:0000303|PubMed:20956536} |
Function | Plays a critical role in cortical radial and GnRH neurons migration during brain development. Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation. CAMDI is required for dilation formation of cortical neurons during radial migration. Plays a critical role in learning and memory performance through regulation of AMPA- selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:E9Q8Q6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:E9Q8Q6}. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. Accumulates and oscillates at the dilation in cortical neurons during migration. CAMDI protein level is stabilized at the G1 phase and destabilized at the G2 /M phase {ECO:0000250|UniProtKB:E9Q8Q6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a critical role in radial migration and centrosomal function.
References
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Fukuda T.,et al.J. Biol. Chem. 285:40554-40561(2010).
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