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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   DCUN1D1 / SCCRO Antibody (C-Terminus)   

DCUN1D1 / SCCRO Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - DCUN1D1 / SCCRO Antibody (C-Terminus) ALS15853
    Anti-DCUN1D1 / SCCRO antibody IHC staining of human kidney.
  • WB - DCUN1D1 / SCCRO Antibody (C-Terminus) ALS15853
    DCUN1D1 antibody (0.5 ug/ml) staining of HepG2 lysate (35 ug protein/ml in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96GG9
Reactivity Human, Mouse, Rabbit, Monkey, Chicken, Horse, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 30kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 54165
Other Names DCN1-like protein 1, DCUN1 domain-containing protein 1, Defective in cullin neddylation protein 1-like protein 1, Squamous cell carcinoma-related oncogene, DCUN1D1, DCUN1L1, RP42, SCCRO
Target/Specificity Human DCUN1D1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDCUN1D1 / SCCRO Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCUN1D1
Synonyms DCUN1L1, RP42, SCCRO
Function Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
Research Areas
Citations (0)

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Background

Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

References

Mas C.,et al.Genomics 65:70-74(2000).
Sarkaria I.,et al.Cancer Res. 66:9437-9444(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Estilo C.L.,et al.Clin. Cancer Res. 9:2300-2306(2003).

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$ 395.00
Cat# ALS15853
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