|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Horse, Bovine, Guinea Pig, Dog|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml),|
|Other Names||Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203|
|Target/Specificity||Human ZIC3. This antibody is expected to NOT cross-react with other ZIC proteins.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ZIC3 Antibody (aa178-189) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Gebbia M.,et al.Nat. Genet. 17:305-308(1997).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
Ross M.T.,et al.Nature 434:325-337(2005).
Zhu L.,et al.Hum. Mutat. 29:99-105(2008).
Bedard J.E.,et al.PLoS ONE 6:E23755-E23755(2011).
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