ZIC3 Antibody (aa178-189)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | O60481 |
Reactivity | Human, Mouse, Rat, Rabbit, Monkey, Horse, Bovine, Guinea Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 51kDa |
Dilution | ELISA (1:64000), IHC-P (5 µg/ml), |
Gene ID | 7547 |
---|---|
Other Names | Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203 |
Target/Specificity | Human ZIC3. This antibody is expected to NOT cross-react with other ZIC proteins. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | ZIC3 Antibody (aa178-189) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZIC3 |
---|---|
Synonyms | ZNF203 |
Function | Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC- 3'. |
Cellular Location | Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity) Translocation to the nucleus requires KPNA1 or KPNA6. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
References
Gebbia M.,et al.Nat. Genet. 17:305-308(1997).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
Ross M.T.,et al.Nature 434:325-337(2005).
Zhu L.,et al.Hum. Mutat. 29:99-105(2008).
Bedard J.E.,et al.PLoS ONE 6:E23755-E23755(2011).
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