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P2RX4 / P2X4 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - P2RX4 / P2X4 Antibody (Internal) ALS15866
    Anti-P2RX4 / P2X4 antibody IHC staining of human uterus.
    detail
  • WB - P2RX4 / P2X4 Antibody (Internal) ALS15866
    P2RX4 antibody (1 ug/ml) staining of Human Kidney lysate (35 ug protein in RIPA buffer).
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q99571
Reactivity Human, Mouse, Rat, Hamster, Dog
Host Goat
Clonality Polyclonal
Calculated MW 43kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 5025
Other Names P2X purinoceptor 4, P2X4, ATP receptor, Purinergic receptor, P2RX4
Target/Specificity Mouse P2RX4 / P2X4.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsP2RX4 / P2X4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name P2RX4
Function ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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Background

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

References

Garcia-Guzman M.,et al.Mol. Pharmacol. 51:109-118(1997).
Yamagata K.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Korenaga R.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).

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Discontinued
Cat# ALS15866
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