P2RX4 / P2X4 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q99571 |
Reactivity | Human, Mouse, Rat, Hamster, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 43kDa |
Dilution | ELISA (1:16000), IHC-P (5 µg/ml), WB (1-3 µg/ml) |
Gene ID | 5025 |
---|---|
Other Names | P2X purinoceptor 4, P2X4, ATP receptor, Purinergic receptor, P2RX4 |
Target/Specificity | Mouse P2RX4 / P2X4. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | P2RX4 / P2X4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | P2RX4 |
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Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
References
Garcia-Guzman M.,et al.Mol. Pharmacol. 51:109-118(1997).
Yamagata K.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Korenaga R.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
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