SEC62 / TP-1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q99442 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (0.5-1 µg/ml) |
Gene ID | 7095 |
---|---|
Other Names | Translocation protein SEC62, Translocation protein 1, TP-1, hTP-1, SEC62, TLOC1 |
Target/Specificity | Human SEC62. SEC62 antibody is predicted to not cross-react with other SEC proteins. Multiple isoforms of SEC62 are known to exist. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | SEC62 / TP-1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SEC62 |
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Synonyms | TLOC1 |
Function | Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for preprotein translocation.
References
Daimon M.,et al.Biochem. Biophys. Res. Commun. 230:100-104(1997).
Daimon M.,et al.IUBMB Life 48:619-624(1999).
Meyer H.-A.,et al.J. Biol. Chem. 275:14550-14557(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
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