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DDA1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9BW61 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 12kDa |
| Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml) |
| Gene ID | 79016 |
|---|---|
| Other Names | DET1- and DDB1-associated protein 1, Placenta cross-immune reaction antigen 1, PCIA-1, DDA1, C19orf58, PCIA1 |
| Target/Specificity | Human DDA1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | DDA1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DDA1 {ECO:0000303|PubMed:17452440, ECO:0000312|HGNC:HGNC:28360} |
|---|---|
| Function | Functions as a component of numerous distinct DCX (DDB1-CUL4- X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
References
Pick E.,et al.Mol. Cell. Biol. 27:4708-4719(2007).
Deng H.-X.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).
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