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RAPGEF4 / EPAC2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - RAPGEF4 / EPAC2 Antibody (N-Terminus) ALS15880
    Anti-RAPGEF4 / EPAC2 antibody IHC staining of human testis.
    detail
  • IF - RAPGEF4 / EPAC2 Antibody (N-Terminus) ALS15880
    Immunofluorescence of EPAC2 in mouse liver tissue with EPAC2 antibody at 20 µg/mL.
    detail
  • WB - RAPGEF4 / EPAC2 Antibody (N-Terminus) ALS15880
    Western blot analysis of EPAC2 in rat liver tissue lysate with EPAC2 antibody at 1 ug/ml in (A)...
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8WZA2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 116kDa
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 11069
Other Names Rap guanine nucleotide exchange factor 4, Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, EPAC 2, cAMP-regulated guanine nucleotide exchange factor II, cAMP-GEFII, RAPGEF4, CGEF2, EPAC2
Target/Specificity Human RAPGEF4 / EPAC2. At least two isoforms of EPAC2 are known to exist; this antibody will detect only the larger isoform.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsRAPGEF4 / EPAC2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAPGEF4
Synonyms CGEF2, EPAC2
Function Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels
Research Areas
Citations (0)
citation

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Background

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity).

References

Kawasaki H.,et al.Science 282:2275-2279(1998).
Ueno H.,et al.Genomics 78:91-98(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
de Rooij J.,et al.J. Biol. Chem. 275:20829-20836(2000).

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Discontinued
Cat# ALS15880
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