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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KPNA5 Antibody (N-Terminus)   

KPNA5 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - KPNA5 Antibody (N-Terminus) ALS15881
    Anti-KPNA5 antibody IHC staining of human brain, cortex.
  • ICC - KPNA5 Antibody (N-Terminus) ALS15881
    Immunocytochemistry of KPNA5 in EL4 cells with KPNA5 antibody at 5 µg/mL.
  • IF - KPNA5 Antibody (N-Terminus) ALS15881
    Immunofluorescence of KPNA5 in EL4 cells with KPNA5 antibody at 20 µg/mL.
  • WB - KPNA5 Antibody (N-Terminus) ALS15881
    Western blot analysis of KPNA6 in EL4 cell lysate with KPNA5 antibody at 1 ug/ml in (A) the...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession O15131
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 60kDa
Dilution ICC (5 µg/ml), IF (5 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml) ,
Additional Information
Gene ID 3841
Other Names Importin subunit alpha-6, Karyopherin subunit alpha-5, KPNA5
Target/Specificity Human KPNA5. KPNA5 antibody is predicted to not cross-react with other Importin alpha family members.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKPNA5 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KPNA5
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Cellular Location Cytoplasm.
Tissue Location Testis.
Research Areas
Citations (0)

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Background

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

References

Koehler M.,et al.FEBS Lett. 417:104-108(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Melen K.,et al.J. Biol. Chem. 278:28193-28200(2003).

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$ 395.00
Cat# ALS15881
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