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PPHLN1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - PPHLN1 Antibody (Internal) ALS15883
    Anti-PPHLN1 antibody IHC staining of human brain, cortex.
    detail
  • IF - PPHLN1 Antibody (Internal) ALS15883
    Immunofluorescence of Periphilin in human colon tissue with Periphilin antibody at 5 µg/mL.
    detail
  • WB - PPHLN1 Antibody (Internal) ALS15883
    Western blot analysis of Periphilin in mouse colon tissue lysate with Periphilin antibody at 1...
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8NEY8
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 53kDa
Dilution IF (5 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 51535
Other Names Periphilin-1, Gastric cancer antigen Ga50, PPHLN1
Target/Specificity Human PPHLN1 / Periphilin.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPPHLN1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPHLN1 (HGNC:19369)
Function Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457).
Cellular Location Nucleus. Cytoplasm. Chromosome. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457) Localizes to chromatin (PubMed:26022416).
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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Background

Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.

References

Line A.,et al.Br. J. Cancer 86:1824-1830(2002).
Kazerounian S.,et al.J. Biol. Chem. 278:36707-36717(2003).
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Li W.B.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS15883
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