ZGPAT Antibody (C-Terminus)
Chicken Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | Q8N5A5 |
Reactivity | Human |
Host | Chicken |
Clonality | Polyclonal |
Calculated MW | 57kDa |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml) |
Gene ID | 84619 |
---|---|
Other Names | Zinc finger CCCH-type with G patch domain-containing protein, G patch domain-containing protein 6, Zinc finger CCCH domain-containing protein 9, Zinc finger and G patch domain-containing protein, ZGPAT, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP |
Target/Specificity | Human ZGPAT. Multiple isoforms of ZGPAT are known to exist. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | ZGPAT Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZGPAT |
---|---|
Synonyms | GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC |
Function | Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed.. |
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Background
Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
References
Nagase T.,et al.DNA Res. 8:85-95(2001).
Ohara O.,et al.Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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