CAPG Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P40121 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 38kDa |
Dilution | ELISA (1:10000), IHC-P (2.5 µg/ml), WB (1:250) |
Gene ID | 822 |
---|---|
Other Names | Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP |
Target/Specificity | CAPG antibody detects endogenous levels of CAPG protein. Not tested with other proteins. |
Reconstitution & Storage | Store at -20°C for up to one year. |
Precautions | CAPG Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CAPG |
---|---|
Synonyms | AFCP, MCP |
Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
Cellular Location | Nucleus. Cytoplasm Melanosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452} |
Tissue Location | Macrophages and macrophage-like cells. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
References
Dabiri G.A.,et al.J. Biol. Chem. 267:16545-16552(1992).
Suzuki Y.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mishra V.S.,et al.Genomics 23:560-565(1994).
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