|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||3 beta-hydroxysteroid dehydrogenase type 7, 3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-HSD VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, C(27) 3-beta-HSD, 1.1.1.-, Cholest-5-ene-3-beta, 7-alpha-diol 3-beta-dehydrogenase, 188.8.131.52, HSD3B7|
|Target/Specificity||HSD3B7 Antibody detects endogenous levels of total HSD3B7 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||HSD3B7 Antibody (aa121-170) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7- alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein- coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.
Schwarz M.,et al.J. Clin. Invest. 106:1175-1184(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Cheng J.B.,et al.J. Clin. Endocrinol. Metab. 88:1833-1841(2003).
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