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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSD3B7 Antibody (aa121-170)   

HSD3B7 Antibody (aa121-170)

Rabbit Polyclonal Antibody

     
  • IHC - HSD3B7 Antibody (aa121-170) ALS15901
    Anti-HSD3B7 antibody IHC staining of human kidney.
  • WB - HSD3B7 Antibody (aa121-170) ALS15901
    Western blot of extracts from HeLa/MCF-7/COLO cells, using HSD3B7 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H2F3
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 80270
Other Names 3 beta-hydroxysteroid dehydrogenase type 7, 3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-HSD VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, C(27) 3-beta-HSD, 1.1.1.-, Cholest-5-ene-3-beta, 7-alpha-diol 3-beta-dehydrogenase, 1.1.1.181, HSD3B7
Target/Specificity HSD3B7 Antibody detects endogenous levels of total HSD3B7 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsHSD3B7 Antibody (aa121-170) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSD3B7
Function The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7- alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein- coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Volume 50 µl
Research Areas
Citations (0)

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Background

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.

References

Schwarz M.,et al.J. Clin. Invest. 106:1175-1184(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Cheng J.B.,et al.J. Clin. Endocrinol. Metab. 88:1833-1841(2003).

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$ 395.00
Cat# ALS15901
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