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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   CEP290 Antibody (aa771-820)   

CEP290 Antibody (aa771-820)

Rabbit Polyclonal Antibody

     
  • IHC - CEP290 Antibody (aa771-820) ALS15910
    Anti-CEP290 antibody IHC staining of human pancreas.
  • WB - CEP290 Antibody (aa771-820) ALS15910
    Western blot of extracts from K562 cells, using CEP290 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O15078
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 290kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 80184
Other Names Centrosomal protein of 290 kDa, Cep290, Bardet-Biedl syndrome 14 protein, Cancer/testis antigen 87, CT87, Nephrocystin-6, Tumor antigen se2-2, CEP290, BBS14, KIAA0373, NPHP6
Target/Specificity CEP290 Antibody detects endogenous levels of total CEP290 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCEP290 Antibody (aa771-820) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEP290
Synonyms BBS14, KIAA0373, NPHP6
Function Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells. Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
Tissue Location Ubiquitous. Expressed strongly in placenta and weakly in brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.

References

Sayer J.A.,et al.Nat. Genet. 38:674-681(2006).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Scherer S.E.,et al.Nature 440:346-351(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Eichmueller S.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).

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$ 395.00
Cat# ALS15910
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