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>   home   >   Products   >   Primary Antibodies   >   TJP1 / ZO-1 Antibody (C-Terminus)   

TJP1 / ZO-1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - TJP1 / ZO-1 Antibody (C-Terminus) ALS15917
    Anti-TJP1 / ZO-1 antibody IHC staining of human kidney.
  • IF - TJP1 / ZO-1 Antibody (C-Terminus) ALS15917
    Immunofluorescence of primary RPE cells with ZO-1 antibody at 1:100 dilution.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q07157
Reactivity Human, Mouse, Rat, Monkey, Dog
Host Goat
Clonality Polyclonal
Calculated MW 195kDa
Dilution IF (1:50-1:250), IHC-P (10 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 7082
Other Names Tight junction protein ZO-1, Tight junction protein 1, Zona occludens protein 1, Zonula occludens protein 1, TJP1, ZO1
Target/Specificity Detects endogenous levels of total ZO-1 by Western blot in whole cell and tissue lysates.
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsTJP1 / ZO-1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TJP1
Synonyms ZO1
Function The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells
Tissue Location The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules
Volume 100 µl
Citations (0)

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Background

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

References

Willott E.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7834-7838(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Cohen C.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:15191-15196(2001).
D'Atri F.,et al.J. Biol. Chem. 277:27757-27764(2002).

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$ 395.00
Cat# ALS15917
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