MDM4 / MDMX Antibody (clone 4G5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | O15151 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 4G5 |
Calculated MW | 55kDa |
Dilution | IF (1:100), IHC-P (10 µg/ml), WB (1:2000) |
Gene ID | 4194 |
---|---|
Other Names | Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX |
Target/Specificity | Human MDM4 / MDMX |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | MDM4 / MDMX Antibody (clone 4G5) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MDM4 |
---|---|
Synonyms | MDMX |
Function | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in all tissues tested with high levels in thymus |
Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
References
Shvarts A.,et al.Genomics 43:34-42(1997).
Giglio S.,et al.Cancer Res. 65:9687-9694(2005).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Rallapalli R.,et al.J. Cell. Biochem. 89:563-575(2003).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.