|Application ||WB, IHC-P, IF|
|Dilution||IF (1:100), IHC-P (10 µg/ml), WB (1:2000)|
|Other Names||Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX|
|Target/Specificity||Human MDM4 / MDMX|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MDM4 / MDMX Antibody (clone 4G5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.|
|Tissue Location||Expressed in all tissues tested with high levels in thymus|
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Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Shvarts A.,et al.Genomics 43:34-42(1997).
Giglio S.,et al.Cancer Res. 65:9687-9694(2005).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Rallapalli R.,et al.J. Cell. Biochem. 89:563-575(2003).
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