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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SYNE3 / C14orf49 Antibody (aa169-218)   

SYNE3 / C14orf49 Antibody (aa169-218)

Rabbit Polyclonal Antibody

     
  • IHC - SYNE3 / C14orf49 Antibody (aa169-218) ALS15935
    Anti-SYNE3 / C14orf49 antibody IHC staining of human testis.
  • WB - SYNE3 / C14orf49 Antibody (aa169-218) ALS15935
    Western blot of extracts from Jurkat cells, using C14orf49 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6ZMZ3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 112kDa
Dilution ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 161176
Other Names Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49
Target/Specificity C14orf49 Antibody detects endogenous levels of total C14orf49 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSYNE3 / C14orf49 Antibody (aa169-218) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNE3
Synonyms C14orf49
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Cellular Location Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum
Tissue Location Expressed in aortic endothelial cells (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells.

References

Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wilhelmsen K.,et al.J. Cell Biol. 171:799-810(2005).
Stewart-Hutchinson P.J.,et al.Exp. Cell Res. 314:1892-1905(2008).

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$ 395.00
Cat# ALS15935
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