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>   home   >   Products   >   Primary Antibodies   >   RBSN / Rabenosyn 5 Antibody (aa145-194)   

RBSN / Rabenosyn 5 Antibody (aa145-194)

Rabbit Polyclonal Antibody

     
  • IHC - RBSN / Rabenosyn 5 Antibody (aa145-194) ALS15939
    Anti-ZFYVE20 / Rabenosyn 5 antibody IHC staining of human kidney.
  • WB - RBSN / Rabenosyn 5 Antibody (aa145-194) ALS15939
    Western blot of extracts from HUVEC/Jurkat cells, using ZFYVE20 Antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H1K0
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 89kDa
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 64145
Other Names Rabenosyn-5, 110 kDa protein, FYVE finger-containing Rab5 effector protein rabenosyn-5, RAB effector RBSN {ECO:0000312|HGNC:HGNC:20759}, Zinc finger FYVE domain-containing protein 20, RBSN (HGNC:20759)
Target/Specificity ZFYVE20 Antibody detects endogenous levels of total ZFYVE20 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsRBSN / Rabenosyn 5 Antibody (aa145-194) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBSN (HGNC:20759)
Function Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface
Volume 50 µl
Citations (0)

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Background

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).

References

Nielsen E.,et al.J. Cell Biol. 151:601-612(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
de Renzis S.,et al.Nat. Cell Biol. 4:124-133(2002).

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$ 395.00
Cat# ALS15939
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