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G3BP2 Antibody (aa433-482)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UN86 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54kDa |
| Dilution | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 9908 |
|---|---|
| Other Names | Ras GTPase-activating protein-binding protein 2, G3BP-2, GAP SH3 domain-binding protein 2, G3BP2, KIAA0660 |
| Target/Specificity | G3BP2 Antibody detects endogenous levels of total G3BP2 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | G3BP2 Antibody (aa433-482) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | G3BP2 {ECO:0000303|PubMed:23279204, ECO:0000312|HGNC:HGNC:30291} |
|---|---|
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, Stress granule |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable scaffold protein that may be involved in mRNA transport.
References
Kennedy D.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Guitard E.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
Kennedy D.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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