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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD22 Antibody (clone 1B1)   

CD22 Antibody (clone 1B1)

Mouse Monoclonal Antibody

     
  • WB - CD22 Antibody (clone 1B1) ALS15976
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD22...
  • IF - CD22 Antibody (clone 1B1) ALS15976
    Anti-CD22 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
  • IHC - CD22 Antibody (clone 1B1) ALS15976
    Anti-CD22 antibody IHC staining of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P20273
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B1
Calculated MW 95kDa
Dilution IF (1:100), IHC-P (5 µg/ml), WB (1:4000)
Additional Information
Gene ID 933
Other Names B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, CD22, SIGLEC2
Target/Specificity Human CD22
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCD22 Antibody (clone 1B1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD22
Synonyms SIGLEC2
Function Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location B-lymphocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

References

Stamenkovic I.,et al.Nature 345:74-77(1990).
Wilson G.L.,et al.J. Exp. Med. 173:137-146(1991).
Wilson G.L.,et al.J. Immunol. 150:5013-5024(1993).
Suzuki Y.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).

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$ 395.00
Cat# ALS15976
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