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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BYJ9 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61kDa |
| Dilution | ELISA (1:1000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 54915 |
|---|---|
| Other Names | YTH domain-containing family protein 1, Dermatomyositis associated with cancer putative autoantigen 1, DACA-1, YTHDF1, C20orf21 |
| Target/Specificity | YTHDF1 Antibody detects endogenous levels of total YTHDF1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | YTHDF1 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | YTHDF1 (HGNC:15867) |
|---|---|
| Function | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A- containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). |
| Cellular Location | Cytoplasm. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Onouchi H.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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