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ADD3 Antibody (aa431-480)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UEY8 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 79kDa |
| Dilution | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 120 |
|---|---|
| Other Names | Gamma-adducin, Adducin-like protein 70, ADD3, ADDL |
| Target/Specificity | ADD3 Antibody detects endogenous levels of total ADD3 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | ADD3 Antibody (aa431-480) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADD3 |
|---|---|
| Synonyms | ADDL |
| Function | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E- cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62847}. Cell membrane {ECO:0000250|UniProtKB:Q62847}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250|UniProtKB:Q9QYB5}. Note=Full- length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q9QYB5} |
| Tissue Location | [Isoform 1]: ubiquitously expressed. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
References
Katagiri T.,et al.Cytogenet. Cell Genet. 74:90-95(1996).
Moorthy S.,et al.Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
Citterio L.,et al.Biochem. Biophys. Res. Commun. 266:110-114(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Deloukas P.,et al.Nature 429:375-381(2004).
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