|Application ||WB, IHC-P, IF, IP, Flo|
|Reactivity||Human, Mouse, Rat, Monkey, Dog|
|Dilution||Flo (1:100), IF (1:50-1:100), IHC-P (10 µg/ml), WB (1:1000-1:2000) ,|
|Other Names||Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB|
|Target/Specificity||Human SSB / La|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SSB / La Antibody (clone 1E11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).|
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Provided below are standard protocols that you may find useful for product applications.
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Chan E.K.L.,et al.Nucleic Acids Res. 17:2233-2244(1989).
Chambers J.C.,et al.J. Biol. Chem. 263:18043-18051(1988).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Hillier L.W.,et al.Nature 434:724-731(2005).
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