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GCP60 / ACBD3 Antibody (clone 2G2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E, IHC-Fr |
|---|---|
| Primary Accession | Q9H3P7 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2G2 |
| Calculated MW | 61kDa |
| Dilution | IF (10 µg/ml), IHC-Fr (1:50), |
| Gene ID | 64746 |
|---|---|
| Other Names | Golgi resident protein GCP60, Acyl-CoA-binding domain-containing protein 3, Golgi complex-associated protein 1, GOCAP1, Golgi phosphoprotein 1, GOLPH1, PBR- and PKA-associated protein 7, Peripheral benzodiazepine receptor-associated protein PAP7, ACBD3, GCP60, GOCAP1, GOLPH1 |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | GCP60 / ACBD3 Antibody (clone 2G2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACBD3 |
|---|---|
| Synonyms | GCP60, GOCAP1, GOLPH1 |
| Function | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion. Note=Also mitochondrial (via its interaction with PBR). |
| Tissue Location | Ubiquitous, with highest expression in testis and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity).
References
Sohda M.,et al.J. Biol. Chem. 276:45298-45306(2001).
Liu J.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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