|Application ||WB, IHC-P, E|
|Dilution||IHC-P (10 µg/ml), WB (1-2 µg/ml),|
|Other Names||Protein crumbs homolog 1, CRB1|
|Target/Specificity||Alternatively spliced transcript variants have been observed. CRB1 antibody is predicted to not cross-react with CRB2.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CRB1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.|
|Cellular Location||Isoform 1: Apical cell membrane; Single-pass type I membrane protein. Note=Distributed at the apical membrane of all retinal epithelial cells. Located in the apical membrane of the adherens junction in outer limiting membrane (OLM) of the retina|
|Tissue Location||Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye|
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Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.
den Hollander A.I.,et al.Nat. Genet. 23:217-221(1999).
den Hollander A.I.,et al.Hum. Mol. Genet. 10:2767-2773(2001).
Kantardzhieva A.,et al.Invest. Ophthalmol. Vis. Sci. 46:2192-2201(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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