CRB1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P82279 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 154kDa |
Dilution | IHC-P (10 µg/ml), WB (1-2 µg/ml), |
Gene ID | 23418 |
---|---|
Other Names | Protein crumbs homolog 1, CRB1 |
Target/Specificity | Alternatively spliced transcript variants have been observed. CRB1 antibody is predicted to not cross-react with CRB2. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | CRB1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CRB1 (HGNC:2343) |
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Function | Plays a role in photoreceptor morphogenesis in the retina (By similarity). May maintain cell polarization and adhesion (By similarity). |
Cellular Location | [Isoform 1]: Apical cell membrane {ECO:0000250|UniProtKB:Q8VHS2}; Single-pass type I membrane protein. Secreted. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8VHS2} Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHS2} |
Tissue Location | Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye (PubMed:15914641) Expressed at the outer limiting membrane and apical to adherens junctions in the retina (PubMed:15914641) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.
References
den Hollander A.I.,et al.Nat. Genet. 23:217-221(1999).
den Hollander A.I.,et al.Hum. Mol. Genet. 10:2767-2773(2001).
Kantardzhieva A.,et al.Invest. Ophthalmol. Vis. Sci. 46:2192-2201(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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