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SDR / SDPR Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - SDR / SDPR Antibody (N-Terminus) ALS16013
    Immunofluorescence of SDPR in human spleen tissue with SDPR antibody at 20 ug/ml.
    detail
  • IHC - SDR / SDPR Antibody (N-Terminus) ALS16013
    Anti-SDR / SDPR antibody IHC staining of human spleen.
    detail
  • WB - SDR / SDPR Antibody (N-Terminus) ALS16013
    Western blot analysis of SDPR in HeLa cell lysate with SDPR antibody at (A) 1 and (B) 2 ug/ml
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O95810
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 8436
Other Names Serum deprivation-response protein, Cavin-2, PS-p68, Phosphatidylserine-binding protein, SDPR {ECO:0000312|EMBL:AAD17795.1}
Target/Specificity It is predicted to not cross-react with other members of the cavin family.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSDR / SDPR Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAVIN2 (HGNC:10690)
Function Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
Cellular Location Cytoplasm, cytosol. Membrane, caveola Note=Localizes in the caveolae in a caveolin-dependent manner
Tissue Location Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
Research Areas
Citations (0)
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Background

May play a role in targeting PRKCA to caveolae.

References

Gustincich S.,et al.Genomics 57:120-129(1999).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bienvenut W.V.,et al.Submitted (NOV-2005) to UniProtKB.
Burgener R.,et al.Biochem. J. 269:729-734(1990).
Carrascal M.,et al.J. Proteome Res. 7:5167-5176(2008).

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Discontinued
Cat# ALS16013
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