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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CRTC2 / TORC2 Antibody (C-Terminus)   

CRTC2 / TORC2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - CRTC2 / TORC2 Antibody (C-Terminus) ALS16020
    Western blot analysis of CRTC2 in human small intestine tissue lysate with CRTC2 antibody at (A)...
  • IF - CRTC2 / TORC2 Antibody (C-Terminus) ALS16020
    Immunofluorescence of CRTC2 in human small intestine tissue with CRTC2 antibody at 20 ug/ml.
  • IHC - CRTC2 / TORC2 Antibody (C-Terminus) ALS16020
    Anti-CRTC2 / TORC2 antibody IHC staining of human testis.
  • IHC - CRTC2 / TORC2 Antibody (C-Terminus) ALS16020
    Anti-CRTC2 / TORC2 antibody IHC staining of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q53ET0
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 200186
Other Names CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, TORC-2, Transducer of CREB protein 2, CRTC2, TORC2
Target/Specificity Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCRTC2 / TORC2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRTC2
Synonyms TORC2
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Cellular Location Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081)
Tissue Location Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas
Research Areas
Citations (0)

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Background

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

References

Iourgenko V.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Conkright M.D.,et al.Mol. Cell 12:413-423(2003).
Screaton R.A.,et al.Cell 119:61-74(2004).

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$ 395.00
Cat# ALS16020
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