|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Apolipoprotein E, Apo-E, APOE|
|Target/Specificity||Human APOE / Apolipoprotein E|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||APOE / Apolipoprotein E Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.|
|Tissue Location||Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle|
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Provided below are standard protocols that you may find useful for product applications.
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Zannis V.I.,et al.J. Biol. Chem. 259:5495-5499(1984).
McLean J.W.,et al.J. Biol. Chem. 259:6498-6504(1984).
Paik Y.-K.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:3445-3449(1985).
Emi M.,et al.Genomics 3:373-379(1988).
Freitas E.M.,et al.DNA Seq. 9:89-100(1998).
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