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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ULK2 Antibody (Internal)   

ULK2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • WB - ULK2 Antibody (Internal) ALS16022
    Western blot analysis of ULK2 in human brain tissue lysate with ULK2 antibody at 1 ug/ml.
  • IF - ULK2 Antibody (Internal) ALS16022
    Immunofluorescence of ULK2 in human brain tissue with ULK2 antibody at 20 ug/ml.
  • IHC - ULK2 Antibody (Internal) ALS16022
    Anti-ULK2 antibody IHC staining of human heart.
  • IHC - ULK2 Antibody (Internal) ALS16022
    Anti-ULK2 antibody IHC staining of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8IYT8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 113kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 9706
Other Names Serine/threonine-protein kinase ULK2, 2.7.11.1, Unc-51-like kinase 2, ULK2, KIAA0623
Target/Specificity At least two isoforms of ULK2 are known to exist; this antibody will detect both isoforms. ULK2 antibody is predicted to not cross-react with ULK1.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsULK2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ULK2
Synonyms KIAA0623
Function Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Cellular Location Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre- autophagosomal membrane
Research Areas
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Background

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

References

Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Chan E.Y.W.,et al.Mol. Cell. Biol. 29:157-171(2009).
Lee E.J.,et al.Autophagy 7:689-695(2011).
Loffler A.S.,et al.Autophagy 7:696-706(2011).

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$ 395.00
Cat# ALS16022
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