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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   TRIM33 / TIF1-Gamma Antibody (Internal)   

TRIM33 / TIF1-Gamma Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • WB - TRIM33 / TIF1-Gamma Antibody (Internal) ALS16027
    Western blot analysis of TRIM33 in human liver tissue lysate with TRIM33 antibody at (A) 1 and...
  • IF - TRIM33 / TIF1-Gamma Antibody (Internal) ALS16027
    Immunofluorescence of TRIM33 in human liver tissue with TRIM33 antibody at 20 ug/ml.
  • IHC - TRIM33 / TIF1-Gamma Antibody (Internal) ALS16027
    Anti-TRIM33 / TIF1-Gamma antibody IHC staining of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9UPN9
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 123kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 51592
Other Names E3 ubiquitin-protein ligase TRIM33, 6.3.2.-, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113, RFG7, TIF1G
Target/Specificity TRIM33 antibody is human, mouse and rat reactive. At least two isoforms of TRIM33 are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTRIM33 / TIF1-Gamma Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM33
Synonyms KIAA1113, RFG7, TIF1G
Function Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
Cellular Location Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
Tissue Location Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors
Research Areas
Citations (0)

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Background

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).

References

Venturini L.,et al.Oncogene 18:1209-1217(1999).
Reymond A.,et al.EMBO J. 20:2140-2151(2001).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
Klugbauer S.,et al.Oncogene 18:4388-4393(1999).

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$ 395.00
Cat# ALS16027
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