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BHLHA15 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - BHLHA15 Antibody (Internal) ALS16039
    Anti-BHLHA15 antibody IHC staining of human testis.
  • WB - BHLHA15 Antibody (Internal) ALS16039
    Western blot analysis of BHLHA15 in rat small Intestine tissue lysate with BHLHA15 antibody at 1...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7RTS1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 168620
Other Names Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1, BHLHA15, BHLHB8, MIST1
Target/Specificity BHLHA15 antibody is human, mouse and rat reactive.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsBHLHA15 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BHLHA15
Synonyms BHLHB8, MIST1
Function Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in brain, liver, spleen and skeletal muscle.
Citations (0)

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Background

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity).

References

Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
McLellan A.S.,et al.Mech. Dev. 119:S285-S291(2002).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 395.00
Cat# ALS16039
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