BHLHA15 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q7RTS1 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 21kDa |
Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml) |
Gene ID | 168620 |
---|---|
Other Names | Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1, BHLHA15, BHLHB8, MIST1 |
Target/Specificity | BHLHA15 antibody is human, mouse and rat reactive. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | BHLHA15 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BHLHA15 |
---|---|
Synonyms | BHLHB8, MIST1 |
Function | Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in brain, liver, spleen and skeletal muscle. |
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Background
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity).
References
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
McLellan A.S.,et al.Mech. Dev. 119:S285-S291(2002).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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