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PSPLA1 / Phospholipase A1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - PSPLA1 / Phospholipase A1 Antibody (C-Terminus) ALS16052
    Immunofluorescence of PLA1A in human kidney tissue with PLA1A antibody at 20 µg/mL.
    detail
  • IHC - PSPLA1 / Phospholipase A1 Antibody (C-Terminus) ALS16052
    Anti-PSPLA1 / PLA1A antibody IHC staining of human brain, cortex.
    detail
  • IF - PSPLA1 / Phospholipase A1 Antibody (C-Terminus) ALS16052
    Immunofluorescence of PLA1A in human kidney tissue with PLA1A antibody at 20 ug/ml.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q53H76
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 51365
Other Names Phospholipase A1 member A, 3.1.1.-, Phosphatidylserine-specific phospholipase A1, PS-PLA1, PLA1A, NMD, PSPLA1
Target/Specificity Human PLA1A. At least three isoforms of PLA1A are known to exist; this antibody will detect all three isoforms.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsPSPLA1 / Phospholipase A1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLA1A (HGNC:17661)
Synonyms NMD, PSPLA1
Function Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1- acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity).
Cellular Location Secreted {ECO:0000250|UniProtKB:P97535}.
Tissue Location Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
Research Areas
Citations (0)
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Background

Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

References

van Groningen J.J.M.,et al.FEBS Lett. 404:82-86(1997).
Nagai Y.,et al.J. Biol. Chem. 274:11053-11059(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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Discontinued
Cat# ALS16052
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