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CD71 / Transferrin Receptor Antibody (aa15-64)

Rabbit Polyclonal Antibody

     
  • WB - CD71 / Transferrin Receptor Antibody (aa15-64) ALS16056
    Western blot of extracts from 293 cells, treated with PMA 125 ng/ml 30', using CD71/TfR (Ab-24)...
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P02786
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 85kDa
Dilution ELISA (1:10000), IHC-P (1:50-1:100), WB (1:500-1:1000)
Additional Information
Gene ID 7037
Other Names Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC
Target/Specificity CD71/TfR (Ab-24) Antibody detects endogenous levels of total CD71/TfR protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCD71 / Transferrin Receptor Antibody (aa15-64) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFRC
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738).
Cellular Location Cell membrane; Single-pass type II membrane protein Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

References

Schneider C.,et al.Nature 311:675-678(1984).
McClelland A.,et al.Cell 39:267-274(1984).
Evans P.,et al.Gene 199:123-131(1997).
Wheeler D.L.,et al.Thesis (1999), University of Iowa, United States.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS16056
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