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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   MCL1 / MCL 1 Antibody (clone 2E11)   

MCL1 / MCL 1 Antibody (clone 2E11)

Mouse Monoclonal Antibody

     
  • WB - MCL1 / MCL 1 Antibody (clone 2E11) ALS16058
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MCL1...
  • IF - MCL1 / MCL 1 Antibody (clone 2E11) ALS16058
    Anti-MCL1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
  • IF - MCL1 / MCL 1 Antibody (clone 2E11) ALS16058
    Immunofluorescent staining of HepG2 cells using anti-MCL1 mouse monoclonal antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, Flo
Primary Accession Q07820
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E11
Calculated MW 37kDa
Dilution Flo (1:100), IF (1:100), IHC-P (1:50), WB (1:2000) ,
Additional Information
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Target/Specificity Human MCL 1
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMCL1 / MCL 1 Antibody (clone 2E11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCL1
Synonyms BCL2L3
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

References

Kozopas K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
Umezawa A.,et al.Cell Struct. Funct. 21:143-150(1996).
Akgul C.,et al.Cell. Mol. Life Sci. 57:684-691(2000).
Bingle C.D.,et al.J. Biol. Chem. 275:22136-22146(2000).
Bae J.,et al.J. Biol. Chem. 275:25255-25261(2000).

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$ 395.00
Cat# ALS16058
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