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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBXL5 / FBL5 Antibody (aa510-691)   

FBXL5 / FBL5 Antibody (aa510-691)

Rabbit Polyclonal Antibody

     
  • WB - FBXL5 / FBL5 Antibody (aa510-691) ALS16064
    0
  • IHC - FBXL5 / FBL5 Antibody (aa510-691) ALS16064
    Anti-FBXL5 / FBL5 antibody IHC staining of human lung.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UKA1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 79kDa
Dilution ELISA (1:20000-1:80000), IHC-P (10 µg/ml), WB (1:1000-1:2000)
Additional Information
Gene ID 26234
Other Names F-box/LRR-repeat protein 5, F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, p45SKP2-like protein, FBXL5, FBL4, FBL5, FLR1
Target/Specificity Human FBXL5.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsFBXL5 / FBL5 Antibody (aa510-691) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXL5
Synonyms FBL4, FBL5, FLR1
Function Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
Cellular Location Cytoplasm, perinuclear region
Research Areas
Citations (0)

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Background

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

References

Winston J.T.,et al.Curr. Biol. 9:1180-1182(1999).
Ilyin G.P.,et al.Genomics 67:40-47(2000).
Shimbara N.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS16064
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