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LTA4H / LTA4 Antibody (clone 9G8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, Flo |
|---|---|
| Primary Accession | P09960 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 9G8 |
| Calculated MW | 69kDa |
| Dilution | Flo (1:100), IF (1:100), IHC-P (10 µg/ml), WB (1:2000) , |
| Gene ID | 4048 |
|---|---|
| Other Names | Leukotriene A-4 hydrolase, LTA-4 hydrolase, 3.3.2.6, Leukotriene A(4) hydrolase, LTA4H, LTA4 |
| Target/Specificity | Human LTA4H / LTA4 |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | LTA4H / LTA4 Antibody (clone 9G8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTA4H |
|---|---|
| Synonyms | LTA4 |
| Function | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti- inflammatory and pro-resolving actions (PubMed:21206090). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
References
Minami M.,et al.J. Biol. Chem. 262:13873-13876(1987).
Funk C.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6677-6681(1987).
Mancini J.A.,et al.Eur. J. Biochem. 231:65-71(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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