|Application ||WB, IHC-P|
|Reactivity||Human, Monkey, Pig, Horse|
|Dilution||IHC-P (5 µg/ml), WB (1-3 µg/ml),|
|Other Names||Engulfment and cell motility protein 3, ELMO3|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ELMO3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).|
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Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
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