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MEPCE Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - MEPCE Antibody (Internal) ALS16077
    Antibody (1 ug/ml) staining of Rat Testis lysate (35 ug protein in RIPA buffer).
    detail
  • IHC - MEPCE Antibody (Internal) ALS16077
    Anti-MEPCE antibody IHC staining of human testis.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q7L2J0
Reactivity Human, Rat, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 74kDa
Dilution ELISA (1:2000), IHC-P (5 µg/ml), WB (1:2000)
Additional Information
Gene ID 56257
Other Names 7SK snRNA methylphosphate capping enzyme, MePCE, 2.1.1.-, Bicoid-interacting protein 3 homolog, Bin3 homolog, MEPCE, BCDIN3
Target/Specificity Human MEPCE.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMEPCE Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEPCE {ECO:0000303|PubMed:30559425, ECO:0000312|HGNC:HGNC:20247}
Function S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723).
Cellular Location Nucleus.
Tissue Location Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis (PubMed:12358911). Weakly or not expressed in other tissues (PubMed:12358911).
Research Areas
Citations (0)
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Background

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Rogers S.A.,et al.Br. J. Haematol. 119:112-114(2002).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).

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Discontinued
Cat# ALS16077
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