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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   UXT Antibody (C-Terminus)   

UXT Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - UXT Antibody (C-Terminus) ALS16078
    UXT antibody (0.03 ug/ml) staining of Human Kidney lysate (35 ug protein/ml in RIPA buffer).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UBK9
Reactivity Human, Rabbit, Monkey, Pig, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 18kDa
Dilution ELISA (1:64000), IHC-P (5 µg/ml), WB (0.01-0.03 µg/ml)
Additional Information
Gene ID 8409
Other Names Protein UXT, Androgen receptor trapped clone 27 protein, ART-27, Ubiquitously expressed transcript protein, UXT
Target/Specificity Human UXT. This antibody is expected to recognize both reported isoforms (NP_004173.1; NP_705582.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsUXT Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UXT
Function Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus
Tissue Location Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.
Research Areas
Citations (0)

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Background

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

References

Schroer A.,et al.Genomics 56:340-343(1999).
Markus S.M.,et al.Mol. Biol. Cell 13:670-682(2002).
McGilvray R.,et al.FEBS J. 274:3960-3971(2007).
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Zhou J.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16078
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