|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (0.3-1 µg/ml),|
|Other Names||Vitamin K-dependent gamma-carboxylase, 220.127.116.11, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, GGCX, GC|
|Target/Specificity||Human GGCX. This antibody is expected to recognize both isoforms (NP_000812.2; NP_001135741.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||GGCX Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
Wu S.-M.,et al.Science 254:1634-1636(1991).
Wu S.-M.,et al.Blood 89:4058-4062(1997).
Ying L.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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