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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UMOD / Uromodulin Antibody (Val378)   

UMOD / Uromodulin Antibody (Val378)

Rabbit Polyclonal Antibody

     
  • WB - UMOD / Uromodulin Antibody (Val378) ALS16093
    Western blot of UMOD (V378) pAb in extracts from K562 cells.
  • IHC - UMOD / Uromodulin Antibody (Val378) ALS16093
    Anti-UMOD / Uromodulin antibody IHC staining of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P07911
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 7369
Other Names Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD
Target/Specificity Human UMOD / Uromodulin
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsUMOD / Uromodulin Antibody (Val378) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UMOD
Function Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).
Cellular Location Apical cell membrane; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860).
Tissue Location Expressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level) Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen
Volume 50 µl
Research Areas
Citations (0)

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Background

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial.

References

Pennica D.,et al.Science 236:83-88(1987).
Hession C.,et al.Science 237:1479-1484(1987).
Hart T.C.,et al.J. Med. Genet. 39:882-892(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).

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$ 395.00
Cat# ALS16093
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