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>   home   >   Products   >   Primary Antibodies   >   SF3B4 Antibody (clone 3A1)   

SF3B4 Antibody (clone 3A1)

Mouse Monoclonal Antibody

     
  • WB - SF3B4 Antibody (clone 3A1) ALS16098
    Blots of HeLa cell crude extract stained with SF3B4 antibody.
  • ICC - SF3B4 Antibody (clone 3A1) ALS16098
    Human HeLa cells stained with SF3B4 antibody (red), chicken antibody to vimentin (green) and DNA...
  • IHC - SF3B4 Antibody (clone 3A1) ALS16098
    Anti-SF3B4 antibody IHC staining of human tonsil.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q15427
Reactivity Human, Mouse, Rat, Pig, Bovine
Host Mouse
Clonality Monoclonal
Clone Names 3A1
Calculated MW 44kDa
Dilution ICC (1:1000), IF (1:1000), IHC-P (10 µg/ml), WB (1:1000) ,
Additional Information
Gene ID 10262
Other Names Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49
Target/Specificity Clone 3A1 is known to react with SF3B4 from human, cow, pig, mouse, rat and other mammals. Since the SF3B4 protein sequence is highly conserved across species barriers, it is likely that the antibody is effective on many other species also.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSF3B4 Antibody (clone 3A1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B4
Synonyms SAP49
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Cellular Location Nucleus.
Volume 50 µl
Citations (0)

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Background

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

References

Champion-Arnaud P.,et al.Genes Dev. 8:1974-1983(1994).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB.
Das R.,et al.Mol. Cell 5:779-787(2000).

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$ 395.00
Cat# ALS16098
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