|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (1-3 µg/ml)|
|Other Names||Threonine synthase-like 2, TSH2, 4.2.3.-, Secreted osteoclastogenic factor of activated T-cells, SOFAT, THNSL2|
|Target/Specificity||Human THNSL2. This antibody is expected to recognize all reported isoforms (NP_060741.3; NP_001231605.1; NP_001231607.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||THNSL2 Antibody (aa192-204) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).|
|Cellular Location||Isoform SOFAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway|
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Provided below are standard protocols that you may find useful for product applications.
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
Rifas L.,et al.Arthritis Rheum. 60:3324-3335(2009).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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