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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   CFTR Antibody (Glu733)   

CFTR Antibody (Glu733)

Rabbit Polyclonal Antibody

     
  • IHC - CFTR Antibody (Glu733) ALS16114
    Anti-CFTR antibody IHC staining of human pancreas.
  • WB - CFTR Antibody (Glu733) ALS16114
    Western blot (WB) analysis of CFTR pAb at 1:500 dilution.Lane1:HEK293T whole cell lysate...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P13569
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 168kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 1080
Other Names Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, 3.6.3.49, cAMP-dependent chloride channel, CFTR, ABCC7
Target/Specificity Human CFTR
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsCFTR Antibody (Glu733) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFTR
Synonyms ABCC7
Function Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Cellular Location Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Note=In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.
Tissue Location Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level)
Research Areas
Citations (0)

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Background

Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

References

Riordan J.R.,et al.Science 245:1066-1073(1989).
Zielenski J.,et al.Genomics 10:214-228(1991).
Stacy R.,et al.Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).

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$ 395.00
Cat# ALS16114
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