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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   PPID / Cyclophilin D Antibody (clone 4C7)   

PPID / Cyclophilin D Antibody (clone 4C7)

Mouse Monoclonal Antibody

     
  • WB - PPID / Cyclophilin D Antibody (clone 4C7) ALS16117
    Western Blot analysis of PPID expression in transfected 293T cell line by PPID monoclonal...
  • IF - PPID / Cyclophilin D Antibody (clone 4C7) ALS16117
    Immunofluorescence of monoclonal antibody to PPID on HeLa cell . [antibody concentration 10 ug/ml]
  • IHC - PPID / Cyclophilin D Antibody (clone 4C7) ALS16117
    Anti-PPID / Cyclophilin D antibody IHC staining of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q08752
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4C7
Calculated MW 41kDa
Dilution IF (10 µg/ml), IHC-P (10 µg/ml),
Additional Information
Gene ID 5481
Other Names Peptidyl-prolyl cis-trans isomerase D, PPIase D, 5.2.1.8, 40 kDa peptidyl-prolyl cis-trans isomerase, Cyclophilin-40, CYP-40, Cyclophilin-related protein, Rotamase D, PPID, CYP40, CYPD
Target/Specificity Human PPID / Cyclophilin D
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPPID / Cyclophilin D Antibody (clone 4C7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPID
Synonyms CYP40, CYPD
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.
Cellular Location Cytoplasm. Nucleus, nucleolus Nucleus, nucleoplasm
Tissue Location Widely expressed.
Volume 50 µl
Research Areas
Citations (0)

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Background

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

References

Kieffer L.J.,et al.J. Biol. Chem. 268:12303-12310(1993).
Yokoi H.,et al.Genomics 35:448-455(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).

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$ 450.00
Cat# ALS16117
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